ORTHOVISC®

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    Safety

    When considering a viscosupplement, clinicians look for a product that closely resembles the properties of healthy synovial fluidSynovial Fluid
    A lubricating fluid resembling the white of an egg, secreted by certain membranes, as those of the joints; also called joint fluid     and product purity. ORTHOVISC® offers both as a safe and lasting non-drug relief choice.

    Protein concentration shows product impurity level and is measured in ppm (parts per million). In comparison, ORTHOVISC® at 2 ppm, has a lower protein concentration than competitive Hyaluronic Acid products.1  Low protein concentration may minimize the risk of inflammatory reactions.1,2  Chemically modified hyaluronanHyaluronan/Hyaluronate
    A substance found naturally in joint fluid that acts as a shock absorber and lubricant in the knee joint and is necessary for the joint to function properly.     sources contain more immunogenicImmunogenic
    Relating to or producing an immune response     cross-linked proteins and have been associated with an increased risk of pseudosepsis.1

    No pseudoseptic reactions have been reported with ORTHOVISC® in more than 1 million injections.3  Repeat courses of ORTHOVISC® may be safely administered.4

     

    SAFE AND LASTING NON-DRUG RELIEF

    SAFE AND LASTING NON-DRUG RELIEF

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    This site is published by DePuy Mitek, Inc., which is solely responsible for its contents.
    It is intended for healthcare professionals in the U.S. and contains U.S. based product information only.
    ORTHOVISC® is manufactured by and is a registered trademark of Anika Therapeutics, Inc. Distributed by DePuy Mitek, Inc.

    © DePuy Mitek, Inc. 2005 - 2010

    AN OFFICIAL HEALTH AND FITNESS PROVIDER

    Important Safety Information

    ORTHOVISC® is indicated in the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and to simple analgesics, e.g. acetaminophen. In clinical studies, the most commonly reported adverse events were arthralgia, back pain, and headache. Other side effects included local injection site adverse events.

    ORTHOVISC® is contraindicated in patients with known hypersensitivity to hyaluronate formulations or known hypersensitivity (allergy) to gram positive bacterial proteins. ORTHOVISC® should not be injected in patients with infections or skin diseases in the area of the injection site or joint. Strict aseptic technique should be used. The effectiveness of more than 1 course has not been established.

    REFERENCES

    1. Data on File, DePuy Mitek, Inc., Raynham, MA
    2. Goldberg,VM. Pseudoseptic Reactions to Hyalgan Viscosupplementation- Diagnosis and Treatment, Clinical Orthopedics, 2004; 419:130-137.
    3. MedLine and FDA Maude/MDR database searches, October 2008
    4. ORTHOVISC® (High Molecular Weight Hyaluronan) manufacturer's full prescribing information